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Peptide sequence: HCVHKFHSLP KSGEKPEADR NPPVLYHNSR ARSTGACNCG RKQAPRDDPF
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Amplified in breast cancer gene 2 protein; FLJ10587; FLJ23205; Nonsense-mediated mRNA decay factor SMG8; Protein smg-8 homolog; smg-8 homolog, nonsense mediated mRNA decay factor; SMG8 nonsense mediated mRNA decay factor
基因别名: ABC2; C17orf71; SMG8
UniProt ID: (Human) Q8ND04
Entrez Gene ID: (Human) 55181