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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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MA5-14282 targets p18INK4c in IF, IHC (P), IP, and WB applications and shows reactivity with Human and mouse samples.
The MA5-14282 immunogen is purified recombinant p18INK4c protein.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。