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Recommended positive controls: HeLa , HCT116.
Predicted reactivity: Mouse (95%), Rat (93%), Dog (98%), Pig (97%), Chicken (90%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; Serine-protein phosphatase FIG4
基因别名: ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; SAC3; YVS
UniProt ID: (Human) Q92562
Entrez Gene ID: (Human) 9896
分子生物学功能: phosphatase