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GFAP-R416WT Monoclonal Antibody (N206B/9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
75-279
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N206B/9
Immunogen
Synthetic peptide amino acids 411-422 of human GFAP (accession number P14136).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: KTVEMRDGEV IK
Target Information
GFAP (R416W) refers to a specific mutation in the GFAP gene, where arginine (R) at position 416 is substituted with tryptophan (W). GFAP, or Glial Fibrillary Acidic Protein, is an intermediate filament protein expressed in astrocytes, providing structural support to these glial cells in the central nervous system. The R416W mutation is associated with Alexander disease, a rare neurodegenerative disorder characterized by the accumulation of GFAP aggregates, leading to astrocyte dysfunction and progressive neurological impairment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GFAP; glial fibrillary acidic protein; glial fibrillary acidic protein (GFAP); glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; intermediate filament; intermediate filament protein; unnamed protein product
Gene Aliases: ALXDRD
UniProt ID: (Human) P14136, (Mouse) P03995, (Rat) P47819
Entrez Gene ID: (Human) 2670, (Mouse) 14580, (Rat) 24387
neural crest cell migration
regulation of protein complex assembly
intermediate filament organization
response to ethanol
enteric nervous system development
positive regulation of glial cell proliferation
regulation of chaperone-mediated autophagy
intracellular protein transport
gene expression
positive regulation of Schwann cell proliferation
negative regulation of neuron projection development
astrocyte development
extracellular matrix organization
neuron projection regeneration
intermediate filament-based process
regulation of neurotransmitter uptake
Bergmann glial cell differentiation
long-term synaptic potentiation
D-aspartate import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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