Product References
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Acta neuropathologica communications
Jeong A,Cheng S,Zhong R,Bennett DA,Bergö MO,Li L
Published figure using HDJ2 monoclonal antibody (Product # MA5-12748) in Western Blot
Tue Jul 27 00:00:00 EDT 2021
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Acta neuropathologica communications
Jeong A,Cheng S,Zhong R,Bennett DA,Bergö MO,Li L
Published figure using HDJ2 monoclonal antibody (Product # MA5-12748) in Western Blot
Tue Jul 27 00:00:00 EDT 2021
ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells.
Cell reports
Luttman JH,Hoj JP,Lin KH,Lin J,Gu JJ,Rouse C,Nichols AG,MacIver NJ,Wood KC,Pendergast AM
Published figure using HDJ2 monoclonal antibody (Product # MA5-12748) in Western Blot
Tue Oct 26 00:00:00 EDT 2021
Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance.
Scientific reports
Blackman JS,Knighton LE,Takakuwa JE,Calderwood SK,Truman AW
MA5-12748 was used in Western Blotting to show Hsp70 co-chaperone DNAJA1 can mediate anti-cancer resistance and sensitize cancer cells to therapeutics.
Fri Aug 14 00:00:00 EDT 2020
The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.
PLoS genetics
Sluder IT,Knighton LE,Truman AW
MA5-12748 was used in Western Blotting to identify the regulatory chaperons involved in ribonucleotide reductase activity.
Thu Nov 01 00:00:00 EDT 2018
Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent.
Proceedings of the National Academy of Sciences of the United States of America
Kyathanahalli C,Organ K,Moreci RS,Anamthathmakula P,Hassan SS,Caritis SN,Jeyasuria P,Condon JC
MA5-12748 was used in western blot to analyze the regulation of gestational length in caspase-3 and -7 dependent involving uterine endoplasmic reticulum stress-unfolded protein response
Tue Nov 10 00:00:00 EST 2015
Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.
Bioorganic & medicinal chemistry
Kabbaj FZ,Lu S,Faouzi Mel A,Meddah B,Proksch P,Cherrah Y,Altenbach HJ,Aly AH,Chadli A,Debbab A
MA5-12748 was used in western blot to study Chaetomium aureum extracts and their effects on Hsp90 machine chaperoning activity
Thu Jan 01 00:00:00 EST 2015
Transcriptional regulation of the human thromboxane A2 receptor gene by Wilms' tumor (WT)1 and hypermethylated in cancer (HIC) 1 in prostate and breast cancers.
Biochimica et biophysica acta
Keating GL,Reid HM,Eivers SB,Mulvaney EP,Kinsella BT
MA5-12748 was used in western blot to study the role of WT1 and HIC in modulating thromboxane A2 receptor transcription in prostate and breast cancers
Sun Jun 01 00:00:00 EDT 2014
Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.
Journal of lipid research
Yang SH,Chang SY,Tu Y,Lawson GW,Bergo MO,Fong LG,Young SG
MA5-12748 was used in western blot to study the development of severe liver disease following conditional knockout of either protein farnesyltransferase or protein geranylgeranyltransferase-1
Sun Jan 01 00:00:00 EST 2012
Ultrasound safety with midfrequency transcranial sonothrombolysis: preliminary study on normal macaca monkey brain.
Ultrasound in medicine & biology
Shimizu J,Fukuda T,Abe T,Ogihara M,Kubota J,Sasaki A,Azuma T,Sasaki K,Shimizu K,Oishi T,Umemura S,Furuhata H
MA5-12748 was used in immunohistochemistry to study the safety of midfrequency ultrasound used for thrombolysis in acute ischemic stroke
Fri Jun 01 00:00:00 EDT 2012
Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1.
Journal of molecular biology
Gannon AM,Turner EC,Reid HM,Kinsella BT
MA5-12748 was used in western blot to investigate the regulatory mechanism for thromboxane A2 receptor alpha isoform expression during megakaryocyte differentiation
Fri Nov 20 00:00:00 EST 2009
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.
The Journal of biological chemistry
Coffinier C,Hudon SE,Lee R,Farber EA,Nobumori C,Miner JH,Andres DA,Spielmann HP,Hrycyna CA,Fong LG,Young SG
MA5-12748 was used in western blot to investigate the effect of darunavir on prelamin A accumulation
Fri Apr 11 00:00:00 EDT 2008
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Blood
Shachaf CM,Perez OD,Youssef S,Fan AC,Elchuri S,Goldstein MJ,Shirer AE,Sharpe O,Chen J,Mitchell DJ,Chang M,Nolan GP,Steinman L,Felsher DW
MA5-12748 was used in western blot to study the mechanism by which atorvastatin inhibition of HMG-CoA reductase prevents and reverses MYC-induced lymphomagenesis
Mon Oct 01 00:00:00 EDT 2007
The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.
Cancer research
Qiu Y,Liu X,Zou W,Yue P,Lonial S,Khuri FR,Sun SY
MA5-12748 was used in western blot to investigate the effect of farnesyltransferase inhibitor R115777 on death receptor 5 expression and apoptosis in human lung cancer cells
Tue May 15 00:00:00 EDT 2007
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Proceedings of the National Academy of Sciences of the United States of America
Coffinier C,Hudon SE,Farber EA,Chang SY,Hrycyna CA,Young SG,Fong LG
MA5-12748 was used in western blot to examine the mechanism for prelamin A accumulation by the treatment of HIV protease inhibitors
Tue Aug 14 00:00:00 EDT 2007
The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells.
The Journal of biological chemistry
Sun SY,Liu X,Zou W,Yue P,Marcus AI,Khuri FR
MA5-12748 was used in western blot to study the effect of farnesyltransferase inhibitor lonafarnib on death receptor 5 expression and apoptosis in human cancer cells
Fri Jun 29 00:00:00 EDT 2007
Heat shock protein 40/DjB1 is required for thermotolerance in early phase.
Journal of biochemistry
Uchiyama Y,Takeda N,Mori M,Terada K
MA5-12748 was used in western blot to examine the role of heat shock protein 40/DjB1 in mammalian thermal response
Fri Dec 01 00:00:00 EST 2006
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Cancer cell
Mijimolle N,Velasco J,Dubus P,Guerra C,Weinbaum CA,Casey PJ,Campuzano V,Barbacid M
MA5-12748 was used in Western Blotting to study the role of protein farnesyltransferase in embryonic development and adult homeostasis.
Fri Apr 01 00:00:00 EST 2005
Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.
Journal of neurochemistry
Nagaoka U,Kim K,Jana NR,Doi H,Maruyama M,Mitsui K,Oyama F,Nukina N
MA5-12748 was used in western blot to investigate the role of p62 in a model of Huntington's disease.
Fri Oct 01 00:00:00 EDT 2004
Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus.
Human molecular genetics
Berciano MT,Villagra NT,Ojeda JL,Navascues J,Gomes A,Lafarga M,Carmo-Fonseca M
MA5-12748 was used in immunocytochemistry to study oculopharyngeal muscular dystrophy-like nuclear inclusions in normal magnocellular neurosecretory neurons of the hypothalamus
Thu Apr 15 00:00:00 EDT 2004
Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Cohen SJ,Ho L,Ranganathan S,Abbruzzese JL,Alpaugh RK,Beard M,Lewis NL,McLaughlin S,Rogatko A,Perez-Ruixo JJ,Thistle AM,Verhaeghe T,Wang H,Weiner LM,Wright JJ,Hudes GR,Meropol NJ
MA5-12748 was used in western blot to investigate the therapeutic efficacy of R115777 in patients with metastatic pancreatic adenocarcinoma
Tue Apr 01 00:00:00 EST 2003
A phase I, pharmacokinetic, and biological study of the farnesyltransferase inhibitor tipifarnib in combination with gemcitabine in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Patnaik A,Eckhardt SG,Izbicka E,Tolcher AA,Hammond LA,Takimoto CH,Schwartz G,McCreery H,Goetz A,Mori M,Terada K,Gentner L,Rybak ME,Richards H,Zhang S,Rowinsky EK
MA5-12748 was used in western blot to perform a phase I clinical trial of a farnesyltransferase inhibitor in combination with gemcitabine in patients with advanced malignancies
Wed Oct 15 00:00:00 EDT 2003
The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research
Delmas C,End D,Rochaix P,Favre G,Toulas C,Cohen-Jonathan E
MA5-12748 was used in western blot to investigate the effect of R115777 on hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft
Mon Dec 01 00:00:00 EST 2003
Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells.
Cancer research
Planey SL,Abrams MT,Robertson NM,Litwack G
MA5-12748 was used in western blot to investigate the mechanism for the glucocorticoid-induced apoptosis of pre-B leukemic cells
Wed Jan 01 00:00:00 EST 2003
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
Molecular cell
Imai Y,Soda M,Hatakeyama S,Akagi T,Hashikawa T,Nakayama KI,Takahashi R
MA5-12748 was used in Western Blot to show that CHIP, Hsp70, Parkin, and Pael-R formed a complex in vitro and in vivo.
Mon Jul 01 00:00:00 EDT 2002
Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein.
Molecular and cellular biology
Lin BY,Makhov AM,Griffith JD,Broker TR,Chow LT
MA5-12748 was used in immunoprecipitation to study the involvement of chaperones in human papillomavirus DNA replication
Sun Sep 01 00:00:00 EDT 2002
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia.
Blood
Peters DG,Hoover RR,Gerlach MJ,Koh EY,Zhang H,Choe K,Kirschmeier P,Bishop WR,Daley GQ
MA5-12748 was used in western blot to investigate the effect of farnesyl protein transferase inhibitor SCH66336 on BCR/ABL-induced murine leukemia and primary chronic myeloid leukemia cells
Thu Mar 01 00:00:00 EST 2001
A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Britten CD,Rowinsky EK,Soignet S,Patnaik A,Yao SL,Deutsch P,Lee Y,Lobell RB,Mazina KE,McCreery H,Pezzuli S,Spriggs D
MA5-12748 was used in western blot to report on a Phase I clinical trial of a peptidomimetic farnesyl protein transferase inhibitor in patients with solid malignancies
Sat Dec 01 00:00:00 EST 2001
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Cancer research
Lobell RB,Omer CA,Abrams MT,Bhimnathwala HG,Brucker MJ,Buser CA,Davide JP,deSolms SJ,Dinsmore CJ,Ellis-Hutchings MS,Kral AM,Liu D,Lumma WC,Machotka SV,Rands E,Williams TM,Graham SL,Hartman GD,Oliff AI,Heimbrook DC,Kohl NE
MA5-12748 was used in western blot to investigate the usefulness of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations on cancer treatment
Sat Dec 15 00:00:00 EST 2001
Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.
Human molecular genetics
Wyttenbach A,Swartz J,Kita H,Thykjaer T,Carmichael J,Bradley J,Brown R,Maxwell M,Schapira A,Orntoft TF,Kato K,Rubinsztein DC
MA5-12748 was used in immunohistochemistry to investigate the effect of polyglutamine expansions on gene expression changes in a Huntington disease model
Wed Aug 15 00:00:00 EDT 2001