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This antibody is predicted to react with Monkey, Bovine, Cat and Rat.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Neurogenic locus notch homolog protein 3; Notch 3; Notch gene homolog 3; Notch homolog 3
基因别名: AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; NOTCH3
UniProt ID: (Human) Q9UM47, (Mouse) Q61982
Entrez Gene ID: (Human) 4854, (Mouse) 18131
分子生物学功能: cell adhesion molecule