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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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MA5-12542 targets Actin Skeletal Muscle in IF and IHC (P) applications and shows reactivity with Amphibian, Bovine, Guinea Pig, Human, Ovine, Rabbit, and Rat samples.
The MA5-12542 immunogen is n-terminal decapeptide.
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: actin alpha 1; actin, alpha 2, smooth muscle, aorta; Actin, alpha skeletal muscle; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; alpha actin; alpha actin 2; Alpha-actin-1; Alpha-actin-2; alpha-cardiac actin; alpha-smooth muscle actin; Cell growth-inhibiting gene 46 protein; cytoplasmic beta-actin; nemaline myopathy type 3; smooth muscle alpha-actin; unnamed protein product
基因别名: 0610041G09Rik; a-SMA; AA959943; AAT6; ACTA; Acta-2; ACTA1; ACTA2; Acts; ACTSA; Actsk-1; ACTVS; alphaSMA; ASMA; CFTD; CFTD1; CFTDM; GIG46; MPFD; MYMY5; NEM1; NEM2; NEM3; SHPM; SMalphaA
UniProt ID: (Human) P68133, (Bovine) P68138, (Rabbit) P62740, (Bovine) P62739, (Human) P04108, (Mouse) P68134, (Rat) P68136, (Rat) P62738, (Mouse) P62737
Entrez Gene ID: (Human) 58, (Bovine) 281592, (Rabbit) 100009506, (Sheep) 101107662, (Rabbit) 100009271, (Bovine) 515610, (Human) 59, (Sheep) 101121051, (Guinea pig) 100716933, (Mouse) 11459, (Rat) 29437, (Rat) 81633, (Mouse) 11475, (Guinea pig) 100722917
分子生物学功能: actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein