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Invitrogen
WNK4 Polyclonal Antibody
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FIGURE: 1 / 1
WNK4 Antibody (PA1-16878) in WB
Western blot analysis of WNK4 in whole cell protein from Hek293. Samples were incubated in WNK4 polyclonal antibody (Product # PA1-16878) using a dilution of 2 µg/mL followed by an anti-rabbit HRP secondary antibody. Separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. Detection: chemiluminescence.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-16878
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a region of the human WNK4 protein between residues 200-300.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is not recommended for ICC/IF applications.
Suggested positive control: mouse kidney lysate or protein.
Target Information
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4; WNK4 Ser/Thr kinase
Gene Aliases: 2010002J11Rik; Ac2-059; Pha2b; PRKWNK4; WNK4
UniProt ID: (Mouse) Q80UE6, (Rat) Q7TPK6
Entrez Gene ID: (Mouse) 69847, (Rat) 287715
protein phosphorylation
ion transport
chloride transport
protein localization
phosphorylation
cellular chloride ion homeostasis
regulation of cellular process
ion homeostasis
renal sodium ion absorption
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
intracellular signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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