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PA1-22870 detects myeloperoxidase in human and rat samples.
PA1-22870 has been successfully used in immunofluorescence, and immunohistochemistry (frozen and paraffin) procedures.
PA1-22870 immunogen is myeloperoxidase isolated from human granulocytes.
Myeloperoxidase (MPO) is a heme protein that is synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single chain precursor and subsequently cleaved into a light and heavy chain. The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme is responsible for producing hypohalous acids that are central to the microbicidal activity of neutrophils. Diseases that are associated with MPO include Myeloperoxidase Deficiency and Alzheimer's Disease, Familial, 1.
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