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Immunogen sequence: SPHRVFHDL LSEQQLLEVE DLSLSLLQGG GLGPLSLPPD LPDLDPECRE LLLDFANSSA ELTGCLVRSA RPVRLCQTCY PLFQQVVSKM DNISRAAGNT SESQSCARSL LMADRMQIVV ILSEFFNTTW QEANCANCLT NNSEELSNST VYFLNLFNHT LTCFEHNLQG NAHSLLQTKN YSEVCKNCRE AYKTLSSLYS EMQKMNELEN KAEPGTHLCI DVEDAMNITR KLWSRTFNCS VPCSDT (38-282 aa encoded by BC068581)
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。