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产品信息
PA5-64727
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human USP28 (Phospho-Ser67) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2664483 |
产品详细信息
Phospho-USP28 (Ser67) Polyclonal Antibody detects endogenous levels of USP28 only when phosphorylated at Ser67.
靶标信息
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
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生物信息学
蛋白别名: Deubiquitinating enzyme 28; Ubiquitin carboxyl-terminal hydrolase 28; ubiquitin carboxyl-terminal hydrolase 28 variant 1; ubiquitin specific protease 28; Ubiquitin thioesterase 28; ubiquitin thiolesterase 28; Ubiquitin-specific-processing protease 28
基因别名: KIAA1515; USP28
UniProt ID: (Human) Q96RU2
Entrez Gene ID: (Human) 57646
分子生物学功能:
cysteine protease
DNA damage checkpoint
DNA repair
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
Ras protein signal transduction
cell proliferation
response to ionizing radiation
protein deubiquitination
regulation of protein stability
cellular response to UV
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
