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The Human TRAIL R3/TNFRSF10C (TRAIL R3) ELISA quantitates Hu TRAIL R3 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu TRAIL R3.
原理方法
The Human TRAIL R3 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
严格验证
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CD263, DCR1, DCR1-TNFR, LIT, TNFRSF10C, TRAIL-R3, TRAILR3, TRID, UNQ321/PRO366
基因ID : (Human) 8794
基因符号 : TNFRSF10C
蛋白别名 : Antagonist decoy receptor for TRAIL/Apo-2L, CD263, cytotoxic TRAIL receptor-3, DcR1, Decoy receptor 1, Decoy TRAIL receptor without death domain, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C, tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
UniProt ID (Human) O14798