G-CSF rescues the memory impairment of animal models of Alzheimer's disease.
AuthorsTsai KJ, Tsai YC, Shen CK,
JournalJ Exp Med
PubMed ID17517969
'Most of the current clinical treatments for Alzheimer''s disease (AD) are largely symptomatic and can have serious side effects. We have tested the feasibility of using the granulocyte colony-stimulating factor (G-CSF), which is known to mobilize hematopoietic stem cells (HSCs) from the bone marrow into the peripheral blood, as a ... More
The effects of anticholinergic insecticides on human mesenchymal stem cells.
AuthorsHoogduijn MJ, Rakonczay Z, Genever PG
JournalToxicol Sci
PubMed ID16960032
'Mesenchymal stem cells (MSCs) are located primarily in the bone marrow and are characterized by their capacity to differentiate into mesenchymal lineages such as bone, fat, and cartilage in response to appropriate signals. Several signaling mechanisms act to control MSC survival, proliferation, and differentiation, and failure or disruption of these ... More
Enhanced purinergic contractile responses and P2X1 receptor expression in detrusor muscle during cycles of hypoxia-glucopenia and reoxygenation.
AuthorsElliott RA, Tonnu A, Ghaffar N, Taylor AH, Tincello DG, Norman RI,
Journal
PubMed ID23975903
'Bladders from patients with detrusor overactivity have an increased atropine-resistant contractile response to nerve stimulation. The bladder has also been shown to be very susceptible to hypoxia-glucopenia and reperfusion injury, leading to the hypothesis that episodes of hypoxia-glucopenia and reoxygenation result in increased atropine-resistant responses to nerve stimulation in the ... More
Role of pancreatic cancer-derived exosomes in salivary biomarker development.
AuthorsLau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT,
Journal
PubMed ID23880764
'Recent studies have demonstrated that discriminatory salivary biomarkers can be readily detected upon the development of systemic diseases such as pancreatic cancer, breast cancer, lung cancer, and ovarian cancer. However, the utility of salivary biomarkers for the detection of systemic diseases has been undermined due to the absence of the ... More
Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon.
AuthorsSuply E, de Vries P, Soret R, Cossais F, Neunlist M,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID22492692
'Postnatal changes in the enteric nervous system (ENS) are involved in the establishment of colonic motility. In adult rats, butyrate induced neuroplastic changes in the ENS, leading to enhanced colonic motility. Whether butyrate can induce similar changes during the postnatal period remains unknown. Enemas (Na-butyrate) were performed daily in rat ... More
Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro.
AuthorsBaldassano S, Wang GD, Mulè F, Wood JD,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID22075777
Glucagon-like peptide-1 (GLP-1) acts at the G protein-coupled receptor, GLP-1R, to stimulate secretion of insulin and to inhibit secretion of glucagon and gastric acid. Involvement in mucosal secretory physiology has received negligible attention. We aimed to study involvement of GLP-1 in mucosal chloride secretion in the small intestine. Ussing chamber ... More
FSH regulates acetycholine production by ovarian granulosa cells.
AuthorsMayerhofer A, Kunz L, Krieger A, Proskocil B, Spindel E, Amsterdam A, Dissen GA, Ojeda SR, Wessler I,
JournalReprod Biol Endocrinol
PubMed ID16846505
BACKGROUND: It has been previously shown that cultured granulosa cells (GCs) derived from human ovarian preovulatory follicles contain choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine (ACh) synthesis. They also produce ACh and express functional muscarinic ACh receptors. ACh can act on GCs to increase proliferation, disrupt gap junctional communication, ... More
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.
AuthorsSchallreuter KU, Elwary SM, Gibbons NC, Rokos H, Wood JM
JournalBiochem Biophys Res Commun
PubMed ID14766237
Previously it has been demonstrated that the human epidermis synthesises and degrades acetylcholine and expresses both muscarinic and nicotinic receptors. These cholinergic systems have been implicated in the development of the epidermal calcium gradient and differentiation in normal healthy skin. In vitiligo severe oxidative stress occurs in the epidermis of ... More