Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation.
AuthorsCsepeggi C, Jiang M, Kojima F, Crofford LJ, Frolov A,
JournalJ Biol Chem
PubMed ID21084287
A growing body of evidence points toward activated fibroblasts, also known as myofibroblasts, as one of the leading mediators in several major human pathologies including proliferative fibrotic disorders, invasive tumor growth, rheumatoid arthritis, and atherosclerosis. Niemann-Pick Type C2 (NPC2) protein has been recently identified as a product of the second ... More
Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice.
AuthorsWang ZH, Shang YY, Zhang S, Zhong M, Wang XP, Deng JT, Pan J, Zhang Y, Zhang W,
JournalDiabetes
PubMed ID22275087
'Insulin resistance triggers the developments of diabetes mellitus and atherosclerosis. Tribbles homolog 3 (TRIB3) is involved in insulin resistance. We aimed to investigate whether TRIB3 is implicated in diabetic atherosclerosis. Sixty 3-week-old apolipoprotein E (ApoE-/-)/LDR receptor (LDLR-/-) mice were randomly divided into chow and diabetes groups. Diabetes was induced by ... More
Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.
AuthorsFuster JJ, González-Navarro H, Vinué A, Molina-Sànchez P, Andrés-Manzano MJ, Nakayama KI, Nakayama K, Díez-Juan A, Bernad A, Rodríguez C, Martínez-González J, Andrés V,
JournalArterioscler Thromb Vasc Biol
PubMed ID21885849
Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atherosclerosis coinciding with enhanced arterial cell proliferation. However, it is unknown whether molecular mechanisms that limit p27's protective function contribute to atherosclerosis development and whether p27 exerts proliferation-independent activities in the arterial wall. This study aims to provide ... More
cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism.
AuthorsStephens RS, Rentsendorj O, Servinsky LE, Moldobaeva A, Damico R, Pearse DB,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID20453163
Increasing evidence suggests that endothelial cytotoxicity from reactive oxygen species (ROS) contributes to the pathogenesis of acute lung injury. Treatments designed to increase intracellular cGMP attenuate ROS-mediated apoptosis and necrosis in several cell types, but the mechanisms are not understood, and the effect of cGMP on pulmonary endothelial cell death ... More
ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration.
AuthorsHortelano S, López-Fontal R, Través PG, Villa N, Grashoff C, Boscá L, Luque A,
JournalCardiovasc Res
PubMed ID20164118
The inflammatory response to injurious agents is tightly regulated to avoid adverse consequences of inappropriate leucocyte accumulation or failed resolution. Lipopolysaccharide (LPS)-activated endothelium recruits leucocytes to the inflamed tissue through controlled expression of membrane-associated adhesion molecules. LPS responses in macrophages are known to be regulated by integrin-linked kinase (ILK); in ... More
TLR4 is the signaling but not the lipopolysaccharide uptake receptor.
AuthorsDunzendorfer S, Lee HK, Soldau K, Tobias PS,
JournalJ Immunol
PubMed ID15240706
TLR4 is the primary recognition molecule for inflammatory responses initiated by bacterial LPS (endotoxin). Internalization of endotoxin by various cell types is an important step for its removal and detoxification. Because of its role as an LPS-signaling receptor, TLR4 has been suggested to be involved in cellular LPS uptake as ... More
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.
AuthorsItoh K, Watanabe A, Funami K, Seya T, Matsumoto M,
JournalJ Immunol
PubMed ID18832709
TLR3 and cytoplasmic RIG-I-like receptor (RLR) recognize virus-derived dsRNA and induce type I IFN production in a distinct manner. Human TLR3 localizes to the endosomal compartments in myeloid dendritic cells (mDCs), while it localizes to both the cell surface and interior in fibroblasts and epithelial cells. TLR3 signaling arises in ... More
Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells.
AuthorsUlvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz RA, Kocks C, Rämet M
JournalJ Biol Chem
PubMed ID16531407
Double-stranded RNA (dsRNA) fragments are readily internalized and processed by Drosophila S2 cells, making these cells a widely used tool for the analysis of gene function by gene silencing through RNA interference (RNAi). The underlying mechanisms are insufficiently understood. To identify components of the RNAi pathway in S2 cells, we ... More
Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ.
AuthorsKuebler WM, Uhlig U, Goldmann T, Schael G, Kerem A, Exner K, Martin C, Vollmer E, Uhlig S
JournalAm J Respir Crit Care Med
PubMed ID12947026
Whereas endothelial responses to shear stress have been studied extensively, the responses to circumferential vascular stretch are yet poorly defined. Circumferential stretch in pulmonary microvessels is largely determined by the transmural pressure gradient, hence by both vascular perfusion and alveolar ventilation pressures. Here, we have studied the production of nitric ... More
The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
AuthorsSano H, Ishino M, Krämer H, Shimizu T, Mitsuzawa H, Nishitani C, Kuroki Y
JournalJ Biol Chem
PubMed ID17237231
The class A scavenger receptor (SR-A) is a multifunctional transmembrane glycoprotein that is implicated in atherogenesis, innate immunity, and cell adhesion. Despite extensive structure-function studies of the receptor, intracellular molecules that directly interact with SR-A and regulate the receptor trafficking have not been determined. In the current study, we have ... More
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
Authors
JournalCell Res
PubMed ID26768768
FLI1 and PKC co-activation promote highly efficient differentiation of human embryonic stem cells into endothelial-like cells.
Authors
JournalCell Death Dis
PubMed ID29374149
Conversion of human fibroblasts to angioblast-like progenitor cells.
Authors
JournalNat Methods
PubMed ID23202434
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Authors
JournalCell Rep
PubMed ID32492423
A single-cell transcriptomic landscape of primate arterial aging.
Authors
JournalNat Commun
PubMed ID32371953
Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain.
Authors
JournalGlia
PubMed ID34487573
Generation, localization and functions of macrophages during the development of testis.
Authors
JournalNat Commun
PubMed ID32873797
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Authors
JournalCell Rep
PubMed ID35172161
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling.