Genexus™ Purification System Extended Warranty & Training Package

The Genexus Purification System Package offers:
• MagMAX technology—enabling consistent extraction results
• Prefilled consumables—helping reduce setup hands-on time
• Vision system—providing real-time feedback on consumables during run setup to prevent setup error
• Integrated nucleic acid quantitation—reducing post-run processing times
• 1 day SmartStart Orientation to get you up and running quickly
• 1- or 2-year AB Assurance extended warranty including comprehensive service coverage and one planned maintenance visit

The Genexus Purification System automates the extraction and quantitation of nucleic acids from a variety of tissue types for use on the Genexus Integrated Sequencer. With a single touch point and 10 minutes of hands-on time, the purification system can extract both DNA and RNA sequentially from FFPE lysates, cfTNA from plasma, and DNA or RNA separately from whole blood, fresh or frozen tissue, bone marrow, or peripheral blood leukocytes. When connected to the integrated sequencer, the Genexus Software streamlines the next-generation sequencing (NGS) workflow by integrating the setup-to-report workflow within a single software ecosystem.

Prefilled reagents
The Genexus Purification System consumables are prefilled with most reagents necessary to perform the extraction, so only a few pipetting steps are required per sample to set up the run. Simply remove the foil seal, add enzymes and your samples, then place the consumables onto the instrument.

Vision system
Just like the Genexus Integrated Sequencer, the Genexus Purification System uses an onboard vision system to verify reagent placement and detect errors in real time. The vision system continuously checks that the consumables are appropriate to the purification run type and helps prevent the running of expired or previously used consumables. Feedback on the consumables loaded in the system is displayed on the screen in the system’s base.

MagMAX technology
MagMAX technology uses magnetic beads to perform nucleic acid extraction. MagMAX beads offer superior binding capacity due to their large surface area, accept a greater range of samples with differing viscosities, and allow for efficient elution in small volumes.

48‐well nucleic acid archive plate
After extraction, all nucleic acids are transferred directly to the 48‐well archive plate and kept cool for up to one hour after run completion. The 48‐well nucleic acid archive plate is barcoded to facilitate the tracking of sample extractions across several stored archive plates.

Automated quantitation
The Genexus Purification System automates quantitation of extracted nucleic acids using an onboard Qubit Fluorometer. Two dyes are used to measure the concentration of DNA or RNA from each extracted sample. Automating post-run quantitation saves hands-on time and allows for immediate use of the extracted samples in genetic analysis workflows after run completion.

Rapid turnaround
Run times on the Genexus Purification System range from 2 to 5.5 hours depending on the number of samples extracted and the protocol being run. Automated quantitation helps significantly reduce post-run hands-on time, allowing for rapid transition to subsequent genetic analysis workflows.

Post-run clean
After each run all consumables that touch the sample are discarded by the researcher after which the Genexus Purification System uses a UV light to clean the deck. This automated UV cleaning prevents possible run-to-run carryover of nucleic acid which could lead to contamination of downstream sequencing.

Get up and running fast with SmartStart Orientation
The SmartStart Orientation included in this package is performed by a Field Application Scientist (FAS) remotely or in your lab and helps you:
• Get up and running quickly
• Get connected to your local network and Cloud
• Choose appropriate reagents and consumables to meet your needs

Content will vary depending on your level of knowledge and experience.

Service plans help protect your investment
Service plans such as the AB Assurance extended warranty included in this package help to:
• Maximize system uptime with fast repair turnaround time from manufacturer-trained and certified field service engineers (FSEs)
• Reduce overall repair costs with remote instrument diagnosis and resolution
• Extend the life of your instrument and help keep it running at peak performance with annual maintenance service

During the annual maintenance, the FSE will update software if required, clean, lubricate, and align relevant parts and optical systems, functional tests as well as document tasks, results, and findings.