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Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1/2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression.
1700027M20Rik; AI429130; bhlh-zip transcription factor SPZ1; NYD-TSP1; PPP1R148; protein phosphatase 1, regulatory subunit 148; spermatogenic leucine zipper 1; spermatogenic leucine zipper protein 1; Spermatogenic Zip 1; SPZ1; testis secretory sperm-binding protein Li 232m; testis-specific protein 1; Testis-specific protein NYD-TSP1; TSP1
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100 µg
100 µg
100 µL