Next-Generation Sequencing (NGS) Assays for Clinical Research

Next-generation sequencing (NGS) is a high-throughput methodology that enables rapid sequencing of the base pairs in DNA or RNA samples. Supporting a broad range of applications, including gene expression profiling, chromosome counting, detection of epigenetic changes, and molecular analysis, NGS is driving discovery and enabling the future of personalized medicine.

Featured targeted NGS applications

Cancer research

Explore our complete Oncomine portfolio of end-to-end next-generation sequencing (NGS) solutions to detect relevant biomarkers in oncology with exceptional speed and accuracy to advance precision oncology research globally.

Reproductive health research

Our solutions for NGS-based expanded carrier screening (ECS) research and preimplantation genetic testing (PGT) offer critical insights that may increase probability of success for future pregnancies and healthier future generations.

Infectious disease and microbiology research

The Ion Torrent and Ion AmpliSeq NGS technologies offer multiple solutions with advantages for clinical researchers studying infectious diseases and other microbial application areas to facilitate rapid and accurate sequencing of microbes.

Inherited disease research

From targeted gene panels to exomes for inherited disease research, our NGS solutions help clinical researchers discover causal variants easily with the simple and rapid Ion Torrent sequencing workflow.

Custom Ion AmpliSeq targeted NGS panels

Get exceptional flexibility and speed for pivotal results with Ion AmpliSeq panels.

 

When navigating through the complexities of NGS testing in clinical research applications, you need a solution that is both flexible and rapid for analyzing variants and regions of interest. Ion AmpliSeq technology can help. It is globally used as an amplicon-based enrichment method for targeted NGS. Clinical researchers worldwide choose Ion AmpliSeq technology for fast, simple, and scalable NGS solutions.

 

Contact an NGS sales specialist to learn more about Ion AmpliSeq panels for clinical research.

Additional NGS application areas

Human identification (HID)

Forensic DNA analysis and phenotyping, from genotyping to STRs to mitochondrial DNA.

Agrigenomics

Simple, scalable, and affordable NGS for plant and animal genotyping applications.

NGS instruments for clinical research

Thermo Fisher Scientific's Ion Torrent NGS platforms for clinical research offer flexible, fast, and easy-to-use solutions that enable laboratories worldwide to bring NGS testing in-house.

How does Ion Torrent NGS work?

Ion Torrent next-generation sequencing exploits the fact that addition of a dNTP to a DNA polymer releases a hydrogen ion. We measure the pH change resulting from those hydrogen ions using semiconductors, simultaneously measuring millions of such changes to determine the sequence of each fragment.

 

The semiconductor approach—unlike optics or modified nucleotides used in other NGS technologies—helps you implement a fast and simple workflow that scales to your research needs across multiple applications including inherited disease, oncology, infectious disease, human identification, human leukocyte antigen typing, and agrigenomics. 

 

Our targeted sequencing approach introduces a PCR-based sequence enrichment step using Ion AmpliSeq technology that focuses on genes or even genetic variants of interest; a good example is the targeting of oncogenes and tumor suppressors in a cancer research study.

For Research Use Only. Not for use in diagnostic procedures.

PMR: 001392