Antibodies that detect Rubicon can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry and Immunohistochemistry. These antibodies target Rubicon in Human, Rat and Mouse samples. Our Rubicon polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. Find the Rubicon antibody that fits your needs. Choose from 1 of 11 Rubicon antibodies, which have been validated in experiments with 3 publications and 32 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.