The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the Golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1, 4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices.
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