Synthesis of alpha-2, 3-linked sialic acid to Gal(beta-1, 3)GalNAc is mediated by at least 3 distinct beta-galactoside alpha-2, 3-sialyltransferases (EC 188.8.131.52), including ST3GAL4. In contrast, only a single gene encodes the beta-galactoside alpha-2, 6-sialyltransferase, ST6GAL1.
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