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ALS2CR11 has 2 isoforms of the human protein that are produced by alternative splicing. An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The encoded protein contains a calcium-dependent membrane targeting C2 domain. This domain is often found in proteins that are involved in membrane trafficking and signal transduction.
1700052H20Rik; 4930408G06Rik; Als2cr11; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein; amyotrophic lateral sclerosis 2 chromosome region candidate 11; C2 calcium-dependent domain-containing protein 6; C2CD6; testicular tissue protein Li 16
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