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Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
AI465466; AI604979; ANKRD28; ankyrin repeat domain 28; ankyrin repeat domain-containing protein 28; E430019N21Rik; KIAA0379; mKIAA0379; phosphatase interactor targeting K protein; phosphatase interactor targeting protein hnRNP K; PITK; PP6-ARS-A; PPP1R65; protein phosphatase 1, regulatory subunit 65; protein phosphatase 6 ankyrin repeat subunit A; RGD1559931; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
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