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EVI1 (MECOM) is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, cell differentiation, and proliferation. It can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. The EVI1 gene can undergo translocation with the AML1 gene, resulting in overexpression of the EVI1 gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
AML1-EVI-1; AML1-EVI-1 fusion protein; D630039M04Rik; ecotropic viral integration site 1; ecotropic virus integration site 1 protein; Ecotropic virus integration site 1 protein homolog; EVI1; Evi-1; Histone-lysine N-methyltransferase MECOM; Jbo; Mds; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; Mds1-Evi1; Mecom; MGC163392; MGC97004; myelodysplasia syndrome 1 homolog; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome 1 protein homolog; myelodysplasia syndrome-associated protein 1; oncogene EVI1; OTTHUMP00000213163; OTTHUMP00000213164; OTTHUMP00000213165; OTTHUMP00000213187; OTTHUMP00000213192; PR domain 3; PRDM3; RUSAT2; zinc finger protein Evi1; Znfpr1b1
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