FAM105B Antibodies

Antibodies that detect FAM105B can be used in several scientific applications, including Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA and Flow Cytometry. These antibodies target FAM105B in Human, Mouse and Rat samples. Our FAM105B polyclonal antibodies are... Antibodies that detect FAM105B can be used in several scientific applications, including Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA and Flow Cytometry. These antibodies target FAM105B in Human, Mouse and Rat samples. Our FAM105B polyclonal antibodies are developed in Rabbit. These antibodies have... Antibodies that detect FAM105B can be used in several scientific applications, including Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA and Flow Cytometry. These antibodies target FAM105B in Human, Mouse and Rat samples. Our FAM105B polyclonal antibodies are developed in Rabbit. These antibodies have been verified by Relative expression to confirm specificity to FAM105B. Find the FAM105B antibody that fits your needs. Choose from 1 of 8 FAM105B antibodies, which have been validated in experiments with 22 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to... Antibodies that detect FAM105B can be used in several scientific applications, including Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA and Flow Cytometry. These antibodies target FAM105B in Human, Mouse and Rat samples. Our FAM105B polyclonal antibodies are developed in Rabbit. These antibodies have been verified by Relative expression to confirm specificity to FAM105B. Find the FAM105B antibody that fits your needs. Choose from 1 of 8 FAM105B antibodies, which have been validated in experiments with 22 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.

同义词

C79097; deubiquitinating enzyme otulin; FAM105B; family with sequence similarity 105, member B; GUM; gumby; m3Sapc; m7-1Sapc; OTU deubiquitinase with linear linkage specificity; OTU domain-containing deubiquitinase with linear linkage specificity; Otulin; protein FAM105B; ubiquitin thioesterase Gumby; Ubiquitin thioesterase otulin

FAM105B Antibodies

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