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Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation.
2610017J04Rik; AI463119; BC026799; F-box only protein 45; F-box protein 45; F-box/SPRY domain-containing protein 1; FBX45; Fbxo45; hFbxo45; mFbxo45; RGD1311861
400 µL
100 µL