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GPATCH3 is a protein coding gene involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
D930035B09Rik; G patch domain containing 3; G patch domain-containing protein 3; Gpatc3; G-patch domain containing 3; GPATCH3; RGD1311216
100 µL
100 µL