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HABP2 is an extracellularserine protease that binds hyaluronic acid and is involved in celladhesion. The encoded protein is synthesized as a single chain, butthen undergoes an autoproteolytic event to form the functionalheterodimer. Further autoproteolysis leads to smaller, inactivepeptides. This protease is known to cleave urinary plasminogenactivator, coagulation factor VII, and the alpha and beta chains offibrinogen, but not prothrombin, plasminogen, or the gamma chain offibrinogen. Two transcript variants encoding different isoformshave been found for this gene.
AI035669; Factor seven-activating protease; factor VII activating protein; factor VII-activating protease; FSAP; HABP; Habp2; Hepatocyte growth factor activator-like protein; HGFAL; hyaduronic acid-binding protein 2; hyaluronan binding protein 2; hyaluronan-binding protein 2; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form; Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; hyaluronic acid binding protein 2; NMTC5; PHBP; plasma hyalurona; plasma hyaluronan binding protein; plasma hyaluronan-binding protein
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