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Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
AI849071; B cell/myeloid kinase; B-cell/myeloid kinase; BMK; HCK; HCK proto-oncogene, Src family tyrosine kinase; Hctk; Hematopoietic cell kinase; hemopoietic cell kinase; hemopoietic cell tyrosine kinase; JTK9; p56Hck; p56-HCK; p56-HCK/p59-HCK; p59Hck; p59-HCK/p60-HCK; p61Hck; tyrosine-protein kinase HCK
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