HEF1 Antibodies

Antibodies that detect HEF1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target HEF1 in Human, Mouse, Rat and Non-human primate samples. Our HEF1 monoclonal,... Antibodies that detect HEF1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target HEF1 in Human, Mouse, Rat and Non-human primate samples. Our HEF1 monoclonal, polyclonal and recombinant monoclonal... Antibodies that detect HEF1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target HEF1 in Human, Mouse, Rat and Non-human primate samples. Our HEF1 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Goat. Find the HEF1 antibody that fits your needs. Choose from 1 of 22 HEF1 antibodies, which have been validated in experiments with 5 publications and 39 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the... Antibodies that detect HEF1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target HEF1 in Human, Mouse, Rat and Non-human primate samples. Our HEF1 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Goat. Find the HEF1 antibody that fits your needs. Choose from 1 of 22 HEF1 antibodies, which have been validated in experiments with 5 publications and 39 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.

同义词

Cas scaffolding protein family member 2; CAS2; CASL; CAS-L; cas-like docking; CASS2; Crk-associated substrate lymphocyte-specific protein; Crk-associated substrate related protein Cas-L; CRK-associated substrate-related protein; dJ49G10.2; dJ761I2.1; Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF1; mEF1; Nedd9; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; neural precursor cell expressed, developmentally down-regulated gene 9; p105; p130Cas-related protein; renal carcinoma antigen NY-REN-12

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HEF1 Antibodies

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