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Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
D15F32S1h; D15F37S1; D7H15F32S1; D7H15F37S1; E3 ubiquitin-protein ligase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; HECT and RLD domain containing E3 ubiquitin protein ligase 2; hect domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; HECT-type E3 ubiquitin transferase HERC2; HERC2; Jdf2; Kiaa0393; mKIAA0393; MRT38; p528; probable E3 ubiquitin-protein ligase HERC2; rjs; SHEP1
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