IDH1 (mutant R132G) Antibodies

Antibodies that detect IDH1 (mutant R132G) can be used in several scientific applications, including Immunohistochemistry. These antibodies target IDH1 (mutant R132G) in Human samples. Our IDH1 (mutant R132G) recombinant monoclonal antibodies are developed in Rabbit. Find the IDH1 (mutant... Antibodies that detect IDH1 (mutant R132G) can be used in several scientific applications, including Immunohistochemistry. These antibodies target IDH1 (mutant R132G) in Human samples. Our IDH1 (mutant R132G) recombinant monoclonal antibodies are developed in Rabbit. Find the IDH1 (mutant R132G) antibody that fits your needs.... Antibodies that detect IDH1 (mutant R132G) can be used in several scientific applications, including Immunohistochemistry. These antibodies target IDH1 (mutant R132G) in Human samples. Our IDH1 (mutant R132G) recombinant monoclonal antibodies are developed in Rabbit. Find the IDH1 (mutant R132G) antibody that fits your needs. Choose from 1 of 2 IDH1 (mutant R132G) antibodies, which have been validated in experiments with 4 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for,... Antibodies that detect IDH1 (mutant R132G) can be used in several scientific applications, including Immunohistochemistry. These antibodies target IDH1 (mutant R132G) in Human samples. Our IDH1 (mutant R132G) recombinant monoclonal antibodies are developed in Rabbit. Find the IDH1 (mutant R132G) antibody that fits your needs. Choose from 1 of 2 IDH1 (mutant R132G) antibodies, which have been validated in experiments with 4 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

The IDH1 gene, located on chromosome 2q34, encodes isocitrate dehydrogenase 1, an enzyme that plays a critical role in the citric acid cycle and cellular metabolism by catalyzing the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. The R132G mutation in IDH1 involves the substitution of glycine for arginine at position 132, a hotspot for mutations in various cancers, most notably in gliomas and acute myeloid leukemia (AML). This mutation results in a neomorphic enzyme activity that reduces alpha-ketoglutarate to D-2-hydroxyglutarate, an oncometabolite that contributes to oncogenesis by altering cellular differentiation and epigenetic regulation through inhibition of alpha-ketoglutarate-dependent dioxygenases. The accumulation of D-2-hydroxyglutarate is a hallmark of IDH1-mutant cancers and serves as a diagnostic biomarker. Targeting mutant IDH1 with specific inhibitors has emerged as a therapeutic strategy, aiming to reverse the metabolic and epigenetic aberrations caused by this mutation and provide clinical benefit in cancers harboring this alteration.