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Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
2010016I08Rik; AU020102; C20orf37; dJ794I6.3; HAMAP-Rule:MF_03148}; HLC14-06-P; inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase {ECO:0000255; inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphatase {ECO:0000255; inosine triphosphate pyrophosphohydrolase; Itp; ITPA; ITPase; ITPase {ECO:0000255; My049; My049 protein; Non-canonical purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase {ECO:0000255; non-standard purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase {ECO:0000255; NTPase; NTPase {ECO:0000255; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate diphosphatase {ECO:0000255; Nucleoside-triphosphate pyrophosphatase; nucleoside-triphosphate pyrophosphatase {ECO:0000255; OK/SW-cl.9; Putative oncogene protein hlc14-06-p
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