JNK1/JNK3 Antibodies

Target Information

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms

AI849689; C230008H04Rik; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 3; JNK; Jnk1; JNK1 beta1 protein kinase; JNK1A2; JNK21B1/2; JNK3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3A; JNK3B1; JNK3B2; JNK-46; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase p49 3F12; MAPK 10; MAPK 8; MAPK10; Mapk8; mitogen activated protein kinase 10; mitogen activated protein kinase 8; mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; p493F12; p54 gamma; p54-beta; p54bSAPK; PRKM10; Prkm8; protein kinase mitogen-activated 8; SAPb; SAPK gamma; SAPK(beta); SAPK/Erk/kinase 2; SAPK1; SAPK1b; SAPK1c; SAPK-beta; SAPKC; Serk2; stress activated protein kinase beta; stress-activated protein kinase 1; stress-activated protein kinase 1b; Stress-activated protein kinase 1c; stress-activated protein kinase JNK1; Stress-activated protein kinase JNK3