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Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
AGM5; KIAA1437; leucine rich repeat containing 8 family member A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; Lrrc8; LRRC8A; mKIAA1437; SWELL1; Swelling protein 1; UNQ221/PRO247; Volume-regulated anion channel subunit LRRC8A
100 µg
100 µL
400 µL
100 µg
100 µL
10 µL