MPP8 Antibodies

Antibodies that detect MPP8 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target MPP8 in Human, Mouse and Rat samples. Our MPP8 polyclonal and monoclonal antibodies are... Antibodies that detect MPP8 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target MPP8 in Human, Mouse and Rat samples. Our MPP8 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. These... Antibodies that detect MPP8 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target MPP8 in Human, Mouse and Rat samples. Our MPP8 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to MPP8. Find the MPP8 antibody that fits your needs. Choose from 1 of 15 MPP8 antibodies, which have been validated in experiments with 31 publications and 29 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been... Antibodies that detect MPP8 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target MPP8 in Human, Mouse and Rat samples. Our MPP8 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to MPP8. Find the MPP8 antibody that fits your needs. Choose from 1 of 15 MPP8 antibodies, which have been validated in experiments with 31 publications and 29 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). [UniProt]

同义词

1500035L22Rik; 4930548G07Rik; Ab2-008; AU040635; HSMPP8; M-phase phosphoprotein 8; M-phase phosphoprotein, mpp; M-phase phosphoprotein, mpp8; Mphosph8; MPP8; RGD1305133; TWA3; Two hybrid-associated protein 3 with RanBPM

MPP8 Antibodies

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