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The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.
54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; 90 kDa N-WASP-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3P21; dia interacting protein; dia-interacting protein 1; diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP; DIP1; DIP-1; mDia interacting protein-1; MGC23891; NCK interacting protein with SH3 domain; NCK-interacting protein with SH3 domain; Nckipsd; N-WASP-binding protein; ORF1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; Spin90; VIP54; Wasbp; WASLBP; WASP-interacting SH3-domain protein; WISH; Wiskott-Aldrich syndrome homolog binding protein; Wiskott-Aldrich syndrome protein-binding protein; wiskott-Aldrich syndrome protein-binding protein WISH; wiskott-Aldrich syndrome protein-interacting protein
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