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PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.
PAAF; PAAF1; proteasomal ATPase associated factor 1; proteasomal ATPase-associated factor 1; Protein G-16; Rpn14; WD repeat domain 71; WD repeat-containing protein 71; WDR71
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