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Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
HAMAP-Rule:MF_03028}; Pes; PES1; Pescadillo homolog; pescadillo homolog {ECO:0000255; pescadillo homolog 1, containing BRCT domain; pescadillo homolog 1, containing BRCT domain (zebrafish); pescadillo ribosomal biogenesis factor 1
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