Search Thermo Fisher Scientific
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells. [UniProt]
HsPNLDC1; PARN like, ribonuclease domain containing 1; PARN-like domain-containing protein 1; PNLDC1; poly(A)-specific ribonuclease (PARN)-like domain containing 1; Poly(A)-specific ribonuclease domain-containing protein 1; poly(A)-specific ribonuclease PARN-like domain-containing protein 1; Poly(A)-specific ribonuclease PNLDC1