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SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.
AI840044; C79168; KIAA0610; mKIAA0610; Spart; Spartin; Spartin-like protein; spastic paraplegia 20 (Troyer syndrome); spastic paraplegia 20 (Troyer syndrome) homolog; Spastic paraplegia 20 protein; spastic paraplegia 20, spartin (Troyer syndrome) homolog; spastic paraplegia 20, spartin (Troyer syndrome) homolog (human); SPG20; TAHCCP1; Trans-activated by hepatitis C virus core protein 1
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