Search Thermo Fisher Scientific
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
Gm1365; Gm287; RGD1564460; RP23-392K10.4; Tlr11; Tlr12; Toll-like receptor 11; Toll-like receptor 12
100 µg
100 µg
100 µg
100 µg
200 µL
200 µL
200 µL