TPH1 Antibodies

Antibodies that detect TPH1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunoprecipitation, Immunocytochemistry and ELISA. These antibodies target TPH1 in Human, Rat, Mouse, Rabbit and Non-human primate samples. Our TPH1... Antibodies that detect TPH1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunoprecipitation, Immunocytochemistry and ELISA. These antibodies target TPH1 in Human, Rat, Mouse, Rabbit and Non-human primate samples. Our TPH1 polyclonal, monoclonal and recombinant... Antibodies that detect TPH1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunoprecipitation, Immunocytochemistry and ELISA. These antibodies target TPH1 in Human, Rat, Mouse, Rabbit and Non-human primate samples. Our TPH1 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Sheep. These antibodies have been verified by Relative expression to confirm specificity to TPH1. Find the TPH1 antibody that fits your needs. Choose from 1 of 14 TPH1 antibodies, which have been validated in experiments with 11 publications and 23 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP,... Antibodies that detect TPH1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunoprecipitation, Immunocytochemistry and ELISA. These antibodies target TPH1 in Human, Rat, Mouse, Rabbit and Non-human primate samples. Our TPH1 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Sheep. These antibodies have been verified by Relative expression to confirm specificity to TPH1. Find the TPH1 antibody that fits your needs. Choose from 1 of 14 TPH1 antibodies, which have been validated in experiments with 11 publications and 23 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH (Kuhn et al., 1997).

同义词

indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; Tph1; TPH2; TPRH; TRPH; tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1; tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)

TPH1 Antibodies

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