TRAF4 Antibodies

Target Information

The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.

Synonyms

A530032M13Rik; Cart1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; Cysteine-rich motif associated to RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; msp2; RING finger protein 83; RNF83; RNF83malignant 62; TNF receptor associated factor 4; TNF receptor-associated factor 4; tnf receptor-associated factor 4b; traf4; TRAF4 protein; TRAF4 variant 6; traf4b; tumor necrosis receptor-associated factor 4A