Invitrogen

14-3-3 Pan Recombinant Rabbit Monoclonal Antibody (HL1776)

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产品信息

MA568100

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000-1:20,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL1776

抗原

Recombinant fragment of human 14-3-3.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 14-3-3 alpha; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta/alpha; 14-3-3 protein epsilon; 14-3-3 protein gamma; 14-3-3 protein sigma; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 protein zeta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 sigma; 14-3-3 zeta; 14-3-3d; 14-3-3E; brain protein 14-3-3, beta isoform; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; Epithelial cell marker protein 1; KCIP-1; mitochondrial import stimulation factor L subunit; phospholipase A2; Protein 1054; Protein HS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein tau; protein, theta; Stratifin; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide

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基因别名: 14-3-3; 14-3-3-zeta; 14-3-3E; 14-3-3GAMMA; 1C5; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL2; HEL4; HME1; HS1; KCIP-1; MDCR; MDS; PPP1R170; SFN; YWHAA; YWHAB; YWHAD; YWHAE; YWHAG; YWHAQ; YWHAS; YWHAZ

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UniProt ID: (Human) P31947, (Human) P31946, (Human) P62258, (Human) P61981, (Human) P27348, (Human) P63104

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Entrez Gene ID: (Human) 2810, (Human) 7529, (Human) 7531, (Human) 7532, (Human) 10971, (Human) 7534

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功能
protein binding protein kinase C inhibitor activity protein kinase binding protein domain specific binding phosphoprotein binding cadherin binding involved in cell-cell adhesion transcription corepressor activity protein C-terminus binding enzyme binding protein complex binding histone deacetylase binding phosphoserine binding potassium channel regulator activity MHC class II protein complex binding ubiquitin protein ligase binding ion channel binding poly(A) RNA binding protein heterodimerization activity protein kinase C binding insulin-like growth factor receptor binding receptor tyrosine kinase binding protein N-terminus binding 14-3-3 protein binding transcription factor binding identical protein binding scaffold/adaptor protein
参与通路
regulation of cyclin-dependent protein serine/threonine kinase activity release of cytochrome c from mitochondria keratinocyte development negative regulation of protein kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction intrinsic apoptotic signaling pathway in response to DNA damage regulation of epidermal cell division negative regulation of keratinocyte proliferation positive regulation of cell growth keratinization negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of epidermal cell differentiation positive regulation of protein export from nucleus membrane organization establishment of skin barrier negative regulation of protein serine/threonine kinase activity cell-cell adhesion positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway MAPK cascade protein targeting viral process negative regulation of protein dephosphorylation hippo signaling positive regulation of catalytic activity regulation of mRNA stability negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated cytoplasmic sequestering of protein protein heterooligomerization G2/M transition of mitotic cell cycle neuron migration regulation of heart rate by hormone substantia nigra development hippocampus development cerebral cortex development intracellular signal transduction regulation of membrane repolarization membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of cellular response to heat regulation of potassium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation regulation of signal transduction cellular response to insulin stimulus regulation of neuron differentiation regulation of synaptic plasticity small GTPase mediated signal transduction negative regulation of ion transmembrane transport platelet activation negative regulation of apoptotic process establishment of Golgi localization Golgi reassembly
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