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Invitrogen
14-3-3 sigma Polyclonal Antibody
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14-3-3 sigma Antibody (PA5-23507) in ICC/IF
Immunofluorescence analysis of 4EBP1 was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with 14-3-3 sigma Rabbit Polyclonal Antibody (Product # PA5-23507) at 5 µg/mL concentration in 0.1% BSA and incubated ove... View More
产品信息
PA5-23507
应用
建议稀释比
已发表文章
产品规格
种属反应
Amphibian,
Bovine,
Dog,
Horse,
Human,
Marsupial,
Non-human primate
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 120-170 of human 14-3-3 sigma.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used as immunogen for the antibody is 100% homologous in White-cheeked Gibbon, and 89% in Opossum.
靶标信息
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3sigma; Epithelial cell marker protein 1; HGNC:10773; Stratifin
基因别名: HME1; SFN; YWHAS
UniProt ID: (Human) P31947, (Bovine) Q0VC36
Entrez Gene ID: (Human) 2810, (Bovine) 528453, (Horse) 100057082, (Dog) 487351
regulation of cyclin-dependent protein serine/threonine kinase activity
release of cytochrome c from mitochondria
keratinocyte development
negative regulation of protein kinase activity
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of epidermal cell division
negative regulation of keratinocyte proliferation
positive regulation of cell growth
keratinization
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of epidermal cell differentiation
positive regulation of protein export from nucleus
membrane organization
establishment of skin barrier
negative regulation of protein serine/threonine kinase activity
cell-cell adhesion
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
