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Invitrogen
LAMP5 (BAD-LAMP) Monoclonal Antibody (34.2), eBioscience™
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LAMP5 (BAD-LAMP) Antibody (14-9778-80) in IHC (P)
Immunohistochemistry of formalin-fixed paraffin embedded human tonsil using 1 µg/mL of Rat IgG1 K Isotype Control Purified (left) or 1 µg/mL of Anti-Human LAMP5 (BAD-LAMP) Purified (right) followed by Anti-Rat IgG Biotin, Avidin HRP, and DAB visualization.Nuclei are counterstained with hematoxylin.
产品信息
14-9778-80
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rat
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
34.2
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.09% Sodium Azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The monoclonal antibody 34.2 recognizes human lysosome-associated membrane protein 5 (LAMP5), a member of the LAMP family. LAMP5 differs from other LAMP family members in that its expression is more restricted and is referred to as brain and dendritic cell-associated LAMP-like molecule (BAD-LAMP). In humans, BAD-LAMP is expressed in post-natal neurons and non-activated plasmacytoid dendritic cells. Expression in neurons is localized to intracellular vesicles distributed in specific microdomains along neurites and may play a role in endocytosis. BAD-LAMP is localized to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of plasmacytoid dendritic cells and is lost upon TLR activation.
This 34.2 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using high or low pH antigen retrieval and can be used at less than or equal to 1 µg/mL. This 34.2 antibody has been tested by western blot analysis of reduced SK-N-SH cell lysates and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
Lysosome-associated membrane protein 5 (LAMP5) is a member of the LAMP family. LAMP5 differs from other LAMP family members in that its expression is more restricted and is referred to as brain and dendritic cell-associated LAMP-like molecule (BAD-LAMP). In humans, BAD-LAMP is expressed in post-natal neurons and non-activated plasmacytoid dendritic cells. Expression in neurons is localized to intracellular vesicles distributed in specific microdomains along neurites and may play a role in endocytosis. BAD-LAMP is localized to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of plasmacytoid dendritic cells and is lost upon TLR activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BAD-LAMP; brain and dendritic cell associated LAMP; Brain and dendritic cell-associated LAMP; Brain-associated LAMP-like protein; LAMP family protein C20orf103; LAMP-5; lysosomal-associated membrane protein family, member 5; Lysosome-associated membrane glycoprotein 5; Lysosome-associated membrane protein 5
基因别名: BAD-LAMP; BADLAMP; C20orf103; LAMP-5; LAMP5; UNC-46
UniProt ID: (Human) Q9UJQ1
Entrez Gene ID: (Human) 24141
