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Invitrogen
17 alpha-hydroxyprogesterone Recombinant Mouse Monoclonal Antibody (5B10)
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17 alpha-hydroxyprogesterone Antibody (MA566663) in SDS-PAGE
SDS-PAGE characterization of 17 alpha-hydroxyprogesterone under reducing conditions. Lane M: Protein marker (kDa); Lane 17-α-OH-P: Purified 17 alpha-hydroxyprogesterone Recombinant Monoclonal (Product # MA566663). 17 alpha-hydroxyprogesterone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-373.
产品信息
MA566663
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5B10
抗原
Conjugate of 17-alpha-OH-P hapten and KLH.
偶联物
形式
Liquid
浓度
7.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
17 alpha-hydroxyprogesterone, often abbreviated as 17-OHP, is a naturally occurring steroid hormone and a key intermediate in the biosynthesis of glucocorticoids, androgens, and estrogens. Structurally, it is a derivative of progesterone characterized by a hydroxyl group at the 17th carbon position, which plays a crucial role in its function and metabolism. In clinical contexts, 17-OHP serves as an important biomarker for diagnosing congenital adrenal hyperplasia (CAH), a genetic disorder affecting adrenal steroid synthesis. Elevated levels of 17-OHP in newborns are indicative of CAH due to 21-hydroxylase deficiency, leading to increased androgen production and the potential for abnormal sexual development. Measurement of 17-OHP is routinely performed in neonatal screening programs to promptly identify and manage this condition. Research into 17-OHP continues to advance understanding of steroidogenesis and its implications in various endocrine disorders, while also exploring therapeutic applications of synthetic analogs for reproductive health.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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