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Invitrogen
3-Methylcytosine Polyclonal Antibody
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3-Methylcytosine Antibody (PA5-40098) in ARRAY
A Dot Blot analysis was performed to test the cross reactivity of 3-mC/3-methylcytosine polyclonal antibody (Product # PA5-40098) with synthetic oligonucleotides containing different modified bases. 150 and 50 pmol of the respective oligo's were spotted on the membrane. The antibody was diluted 1:400 in PBS-T containing 10% skimmed milk and 1% BSA. Figure 1 shows a high specificity of the antibody for the o... View More
产品信息
PA5-40098
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human BSA-conjugated 3-methylcytosine (3-mC).
偶联物
形式
Liquid
浓度
1.8 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.05% sodium azide, 0.05% ProClin 300
保存条件
-20°C or -80°C if preferred
RRID
靶标信息
3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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