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Invitrogen
3-hydroxykynurenine Monoclonal Antibody (P3UI)
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3-hydroxykynurenine Antibody (MA1-16616) in IHC (P)
Immunohistochemistry analysis of 3-hydroxykynurenine in immersion fixed paraffin-embedded sections of human brain. Samples were incubated with 3-hydroxykynurenine monoclonal antibody (Product # MA1-16616) using a dilution of 1:300 for 1 hour at room temperature followed by Anti-Mouse IgG VisUCyte HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific ... View More
产品信息
MA1-16616
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
已发表种属
Chemical
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
P3UI
抗原
3-OHKYN modified KLH.
偶联物
形式
Liquid
浓度
2.6 mg/mL
纯化类型
Protein G
保存液
TBS
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive control: 3-OHKYN modified BSA.
靶标信息
3-Hydroxykynurenine (3-HK) is a metabolite in the kynurenine pathway of tryptophan catabolism, primarily involved in various physiological and pathological processes. It is a branch of the kynurenine monooxygenase (KMO) pathway and has been recognized for its dual role in the central nervous system. Structurally, 3-HK is an intermediate metabolite that undergoes autoxidation, which results in a range of products that may contribute to protein modification and cytotoxicity, especially in the context of oxidative stress. Although 3-HK has antioxidant and free radical scavenging properties, it is largely characterized as a toxic metabolite that can induce oxidative damage and cell death. The neuronal damage associated with 3-HK is mediated by free radicals rather than glutamate receptors. Altered levels of 3-HK have been observed in patients with various disorders, suggesting its potential involvement in neurodegenerative diseases. Research continues to explore the balance between its damaging and protective roles, with implications for therapeutic interventions targeting oxidative stress and neuroprotection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
