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Invitrogen
Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor™ 488
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Product Details
352588
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C3C2
Immunogen
Synthetic peptide derived from the mouse Claudin-5 protein
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 4mg/mL BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reactivity has been confirmed with rat, human and mouse Claudin-5 using rat lung, mouse kidney, mouse small intestine, mouse lung homogenates, human colon tissue, and CACO-2 human cell line. This antibody reacts specifically with the ~ 22-24 kDa endogenous Claudin-5 protein. Excitation/Peak Emission (nm): 495/519
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain endothelial cell clone 1 protein; Claudin-5; Lung-specific membrane protein; TMDVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Gene Aliases: AI854493; AWAL; BEC1; CLDN5; CPETRL1; MBEC1; TMVCF
UniProt ID: (Human) O00501, (Rat) Q9JKD6, (Mouse) O54942
Entrez Gene ID: (Human) 7122, (Rat) 65131, (Mouse) 12741
outflow tract morphogenesis
cell-cell junction assembly
transforming growth factor beta receptor signaling pathway
learning
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
palate development
face morphogenesis
positive regulation of establishment of endothelial barrier
myelination
single organismal cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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